Fast perturbation Monte Carlo method for photon migration in heterogeneous turbid media

Perturbation Monte Carlo methods to solve inverse photon migration problems in heterogeneous tissues.

We introduce a novel and efficient method to provide solutions to inverse photon migration problems in heterogeneous turbid media. The method extracts derivative information from a single Monte Carlo simulation to permit the rapid determination of rates of change in the detected photon signal with respect to perturbations in background tissue optical properties. We then feed this derivative inf...

Highly parallel Monte-Carlo simulations of the acousto-optic effect in heterogeneous turbid media.

The development of a highly parallel simulation of the acousto-optic effect is detailed. The simulation supports optically heterogeneous simulation domains under insonification by arbitrary monochromatic ultrasound fields. An adjoint method for acousto-optics is proposed to permit point-source/point-detector simulations. The flexibility and efficiency of this simulation code is demonstrated in ...

Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media.

We show that a multiexponential model for time-resolved fluorescence allows the use of an absorption-perturbation Monte Carlo (MC) approach based on stored photon path histories. This enables the rapid fitting of fluorescence yield, lifetimes, and background tissue absorptions in complex heterogeneous media within a few seconds, without the need for temporal convolutions or MC recalculation of ...

Photon migration in turbid media using path integrals.

Three dimensional Monte Carlo code for photon migration through complex heterogeneous media including the adult human head.

We describe a novel Monte Carlo code for photon migration through 3D media with spatially varying optical properties. The code is validated against analytic solutions of the photon diffusion equation for semi-infinite homogeneous media. The code is also cross-validated for photon migration through a slab with an absorbing heterogeneity. A demonstration of the utility of the code is provided by ...